The home of Manchester United is one of a number of major football stadiums to be used during the tournament, which is being held across England in two years' time.
The Emirates Stadium will host a men’s semi-final, making rugby league the only sport other than football to have been played at the home of Arsenal FC.
The men’s opening ceremony will take place in Newcastle at St. James’ Park, following four successful seasons as the host of rugby league's Magic Weekend.
Other football stadiums to host games include the Ricoh Arena in Coventry, Bramall Lane in Sheffield and Riverside Stadium in Middlesbrough.
Set to be the most inclusive rugby league event ever, RLWC2021 will see the men’s, women’s and wheelchair tournaments played concurrently for the first time.
The women’s and men’s finals will take place as a double-header at Old Trafford, while Liverpool’s M&S Bank Arena will host the wheelchair final.
Tournament organisers have met the Government target of hosting at least 80 per cent of the tournament in the "Northern Powerhouse", with games also taking place in Doncaster, Huddersfield, Hull, Leeds and York.
"With all three tournaments running concurrently, RLWC2021 will give the chance for people across the country to engage in a variety of ways and really look forward to October and November 2021," said Jon Dutton, CEO of RLWC2021.
"This was an incredibly tough process given the large number of interested parties and the impressive nature of their bids.
"Each and every host now has the opportunity to galvanise and inspire their respective communities ahead of the competing nations arriving in England."
The full list of game venues/hosts:
The University of Bolton Stadium
Anfield Stadium, LiverpoolM&S Bank Arena Liverpool
The Totally Wicked Stadium, St HelensOld Trafford, Manchester
The Halliwell Jones Stadium, WarringtonLeigh Sports Village, Wigan
The Ricoh Arena, Coventry
The John Smiths Stadium, KirkleesThe KCOM Stadium, Hull
Elland Road, LeedsEmerald Headingley Stadium, Leeds
Bramall Lane, Sheffield The EIS Sheffield
The Community Stadium, York
The Riverside Stadium, MiddlesbroughSt James’ Park, Newcastle
The Workington Community Stadium, Allerdale
The Emirates Stadium
First published: www.sportsmanagement.co.uk, written by Tom Walker, 31 January 2019